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Title: Unraveling Kidney Physiology, Pathophysiology and Therapeutics: A Modeling Approach
Location and Time: C304 Wells Hall, 4:10pm-5pm, March 6, 2015
Speaker: Professor Anita Layton , Duke University
Abstract: The kidney not only filters metabolic wastes and toxins from the body, but it also
regulates the body's water balance, electrolyte balance, and acid-base balance, blood pressure, and
blood flow. Despite intense research, aspects of kidney functions remain incompletely understand. I
will discuss how our group use mathematical modeling techniques to address a host of previously
unanswered questions in renal physiology and pathophysiology: When deprived of water, how does a
mammal produce a highly concentrated urine? Why is the mammalian kidney so susceptible to hypoxia,
despite receiving ~25% of the cardiac output? What are the mechanisms underlying the development of
acute kidney injury in a patient who has undergone cardiac surgery performed on cardiopulmonary
bypass? What is the effect of inhibiting sodium-glucose transport, a novel treatment for reducing
renal glucose update in diabetes, on renal Nacl transport and oxygen consumption?
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