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-------------- Title: Unraveling Kidney Physiology, Pathophysiology and Therapeutics: A Modeling Approach Location and Time: C304 Wells Hall, 4:10pm-5pm, March 6, 2015 Speaker: Professor Anita Layton , Duke University Abstract: The kidney not only filters metabolic wastes and toxins from the body, but it also regulates the body's water balance, electrolyte balance, and acid-base balance, blood pressure, and blood flow. Despite intense research, aspects of kidney functions remain incompletely understand. I will discuss how our group use mathematical modeling techniques to address a host of previously unanswered questions in renal physiology and pathophysiology: When deprived of water, how does a mammal produce a highly concentrated urine? Why is the mammalian kidney so susceptible to hypoxia, despite receiving ~25% of the cardiac output? What are the mechanisms underlying the development of acute kidney injury in a patient who has undergone cardiac surgery performed on cardiopulmonary bypass? What is the effect of inhibiting sodium-glucose transport, a novel treatment for reducing renal glucose update in diabetes, on renal Nacl transport and oxygen consumption?