 |
 |
From: Shawna Prater Sent: Monday, February 6, 2017 1:56 PM To: [log in to unmask] <[log in to unmask]> Subject: Science at the Edge Friday 11:30 February 10, 2017 SCIENCE AT THE EDGE FRIDAY FEBRUARY 10, 2017, ROOM 1400 BIOMEDICAL PHYSICAL SCIENCES BLDG. 11:30 a.m. Control of Water by Protein Functional Dynamics in two Photoreceptors Jiali Gao, Department of Chemistry, University of Minnesota, and Jilin University, Changchun, China UVR8 and the LOV domain are photoreceptor proteins. Up on photo-excitation, the UVR8 dimer dissociates into monomers and the LOV domain undergoes conformation change, both triggering a range of cell functions. Computation studies show that water plays an integral role of the dimer dissociation process of UVR8 and the dark-state recovery of the covalently linked photoproduct in the LOV domain. In this talk, I will describe computational methods that have been developed to study charge transfer processes in the ultrafast photochemical processes, and analyses of molecular dynamics trajectories that reveal the interplay of protein conformational dynamics and access of water in the active centers of the proteins. Jiali Guowei Wei Host [log in to unmask]<mailto:[log in to unmask]> Michigan State University Dept. Physics and Astronomy Shawna Prater-CHRS Secretary for Astrophysics/CMP Theory POC for Physics SATE seminars/COLLOQUIUM 3261BPS, 567 Wilson Road East Lansing, MI 48824-6405 [log in to unmask]<mailto:[log in to unmask]> fax 517.432.8802 [msu]