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From: Guowei Wei [mailto:[log in to unmask]] Sent: Friday, November 18, 2016 8:51 AM To: Shawna Prater <[log in to unmask]> Subject: Applied Math Seminar today 4:10-5:00pm EB Dear Shawna, Could you forward this seminar information to Science at Edge network? Thanks Guowei Title: Computational Modeling in Studying Blood Clot Formation Date: 11/18/2016 Time: 4:10 pm - 5:00 pm Place: 1502 Eng Building Speaker: Professor Zhiliang Xu, Notre Dame University Abstract: Blood clotting is a multiscale process involving blood cells, fibrinogen polymerization, coagulation reactions, ligand-receptor interactions and blood plasma flow. Detailed multiscale models of blood clotting to cover all aspects of clotting are, if not possible, extremely difficult to develop. Models focusing on specific events across one or two spatial-temporal scales seem to be plausible. In this talk, ligand-receptor binding kinetics model, computational model of fluid-structure interaction (FSI) for simulating flow-elastic membrane with mass and a continuum model for studying the structural stability of clots will be presented. The binding kinetics model revealed that platelet αIIbβ3 integrin and fibrin interacts through a two-step mechanism. The new FSI model is derived by using the energy law and distributed-Lagrange-multiplier/fictitious-domain (DLM/FD) formulation. The continuum model for studying the structural stability of clots utilized the phase field and energetic variational approaches. Simulation results show that rheological response of the blood clot to the flow is determined by mechanical and structural properties of its components. Two main mechanisms are shown to significantly affect volume of the already formed clot: dynamic balance between platelet adhesion and platelet removal by the flow on the blood clot surface and removal of parts of the clot through rupture.