From: Guowei Wei [mailto:[log in to unmask]]
Sent: Thursday, October 27, 2016 11:28 AM
To: Shawna Prater <[log in to unmask]>
Subject: Fwd: Announcement for Tom Chou's talk

Hi Shawna,

Could you forward this seminar to Science at Edge netters? The speaker has a PhD in physics.

Best

Guowei

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Guowei Wei,
Professor
Departments of Mathematics,
Electrical and Computer Engineering, and
Biochemistry and Molecular Biology
Michigan State University
http://math.msu.edu/~wei
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Applied Mathematics Seminar

Speaker: Tom Chou, Professor of Mathematics, UCLA

Friday October 28, 4:10 PM - 5:00 PM; 1502 Engineering Building

"Path integral-based inference of PDEs and bond energies and mobility in Dynamic Force Spectroscopy"

A Bayesian interpretation is given for regularization terms for parameter functions in inverse problems. Fluctuations about the extremal solution depend on the regularization terms - which encode prior knowledge - provide quantification of uncertainty. After reviewing a general path-integral framework, we discuss an application that arises in molecular biophysics: The inference of bond energies and bond coordinate mobilities from dynamic force spectroscopy experiments.