From: Guowei Wei [mailto:[log in to unmask]] Sent: Thursday, October 27, 2016 11:28 AM To: Shawna Prater <[log in to unmask]> Subject: Fwd: Announcement for Tom Chou's talk Hi Shawna, Could you forward this seminar to Science at Edge netters? The speaker has a PhD in physics. Best Guowei ----------------------------------------------------------------------- Guowei Wei, Professor Departments of Mathematics, Electrical and Computer Engineering, and Biochemistry and Molecular Biology Michigan State University http://math.msu.edu/~wei ----------------------------------------------------------------------- Applied Mathematics Seminar Speaker: Tom Chou, Professor of Mathematics, UCLA Friday October 28, 4:10 PM - 5:00 PM; 1502 Engineering Building "Path integral-based inference of PDEs and bond energies and mobility in Dynamic Force Spectroscopy" A Bayesian interpretation is given for regularization terms for parameter functions in inverse problems. Fluctuations about the extremal solution depend on the regularization terms - which encode prior knowledge - provide quantification of uncertainty. After reviewing a general path-integral framework, we discuss an application that arises in molecular biophysics: The inference of bond energies and bond coordinate mobilities from dynamic force spectroscopy experiments.