SCIENCE AT THE EDGE, INTERDISCIPLINARY PHYSICS
Fri, 18 Mar 2016, 11:30 am - 12:30 pm
1400 BPS Bldg.
Mark Goulian
Department of Biology and Department of Physics & Astronomy, University of Pennsylvania
Bacterial Signal Transduction: an
E. coli View of the World
Abstract:
All cells sense and respond to physical and chemical cues in their environments. They accomplish this through
signal transduction systems—networks of interacting proteins that detect and interpret specific input signals and control appropriate cellular responses. In bacteria, one of the major modes of signal transduction is mediated by a class of circuits that are
composed of two components: a sensory protein and a response regulator. These two-component systems have been found in remarkable numbers within individual organisms and across different bacterial species. They play a central role in regulating basic aspects
of microbial physiology and mediate responses to diverse environmental signals. I will describe recent work in which we have explored the organization and properties of these circuits in the particularly well studied and genetically tractable organism
Escherichia coli.
Refreshments at 11:15 am.
Shawna Prater / Secretary
Astrophysics Group
Michigan State University
567 Wilson Road, Room 3261
Biomedical Physical Sciences Bldg
East Lansing, MI 48824-2320
Ph: (517) 884-5601 Fax (517) 432-8802
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