Dr. Rafael Casellas is the Science at the Edge seminar speaker on Friday, October 18.  His abstract is below and attached to this message.  Dr. Kefei Yu is hosting the speaker  If you would like to meet with Dr. Casellas, please reply to this message with your available times (flexibility is helpful in scheduling the appointments) and I will get back with you to confirm the time. 

Friday, October 18

7:45-9:00          Open – Breakfast w/speaker (he is staying at Kellogg Center and charge meal to his room)

9:00-9:45          Open

9:45-10:30        Filled

10:30-11:15      Filled

11:15-11:30      Speaker Preparation, 1425 BPS

11:30-12:30      Seminar, 1425 BPS

12:30-2:00        Filled – Lunch w/speaker

2:00-2:45          Filled

2:45-3:30          Filled

3:30-4:15          Open

4:15                  Dr. Yu takes Dr. Casellas to the airport

The National Institutes of Health recently launched the NIH Mouse Regulome Project (NMRP), an initiative that seeks to characterize all gene-regulatory elements and ranscription factor binding sites in the mouse genome. This is achieved by mapping genome-wide DNA methylation, chromatin modifications that demarcate promoters and enhancers, PolII binding, transcriptome analyses, and DNAseI hypersensitivity. In contrast to the previous human ENCODE project, which assigned enhancers to cognate promoters based on proximity, the NMRP makes use of a newly developed deep-sequencing technique (ChIA-PET) that precisely maps promoter-enhancer interactions with unprecedented detail. To complement these efforts, a Genome Editing facility was created to assemble hundreds of zinc finger nucleases with the goal of deleting regulatory domains and study their activity in vivo. The seminar will highlight the applications of these technologies to mouse ES cells and B lymphocytes.

Helen Geiger

Administrative Assistant

Quantitative Biology Graduate Program and

Gene Expression in Development and Disease

212 Biochemistry Building

Michigan State University

East Lansing, MI   48824

Email: [log in to unmask]

Phone:  517-432-9895

QB Website: http://www.qbi.msu.edu/

GEDD Website: http://www.gedd.msu.edu/