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Dr. Rafael Casellas is the Science at the Edge seminar speaker on Friday, October 18. His abstract is below and attached to this message. Dr. Kefei Yu is hosting the speaker If you would like to meet with Dr. Casellas, please reply to this message with your available times (flexibility is helpful in scheduling the appointments) and I will get back with you to confirm the time. Friday, October 18 7:45-9:00 Open - Breakfast w/speaker (he is staying at Kellogg Center and charge meal to his room) 9:00-9:45 Open 9:45-10:30 Filled 10:30-11:15 Filled 11:15-11:30 Speaker Preparation, 1425 BPS 11:30-12:30 Seminar, 1425 BPS 12:30-2:00 Filled - Lunch w/speaker 2:00-2:45 Filled 2:45-3:30 Filled 3:30-4:15 Open 4:15 Dr. Yu takes Dr. Casellas to the airport Rafael Casellas Genomics & Immunity, NIAMS NIH, Bethesda, MD The NIH Mouse Regulome Project The National Institutes of Health recently launched the NIH Mouse Regulome Project (NMRP), an initiative that seeks to characterize all gene-regulatory elements and ranscription factor binding sites in the mouse genome. This is achieved by mapping genome-wide DNA methylation, chromatin modifications that demarcate promoters and enhancers, PolII binding, transcriptome analyses, and DNAseI hypersensitivity. In contrast to the previous human ENCODE project, which assigned enhancers to cognate promoters based on proximity, the NMRP makes use of a newly developed deep-sequencing technique (ChIA-PET) that precisely maps promoter-enhancer interactions with unprecedented detail. To complement these efforts, a Genome Editing facility was created to assemble hundreds of zinc finger nucleases with the goal of deleting regulatory domains and study their activity in vivo. The seminar will highlight the applications of these technologies to mouse ES cells and B lymphocytes. Helen Geiger Administrative Assistant Quantitative Biology Graduate Program and Gene Expression in Development and Disease 212 Biochemistry Building Michigan State University East Lansing, MI 48824 Email: [log in to unmask]<mailto:[log in to unmask]> Phone: 517-432-9895 QB Website: http://www.qbi.msu.edu/ GEDD Website: http://www.gedd.msu.edu/ <10-18-13CasellasAbstractFlyer.doc> Katheryn Meek, Professor Microbiology & Molecular Genetics, Pathobiology & Diagnostic Investigation Biomedical and Physical Sciences Building 567 Wilson Rd., Rm 2215 Michigan State University East Lansing, MI 48824 [log in to unmask]<mailto:[log in to unmask]>