SCIENCE AT THE EDGE SEMINAR QB/GEDD Friday, April 19 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Ian Korf Genome Center University of California, Davis Genomics and Bioinformatics to the Rescue: Solving Complex Problems with Simple Models and Loads of Data Recent advances in high throughput biology and information technology have changed how we investigate and understand the biological world. 10 years ago, the few genomes that were available had been sequenced by international consortia and had price tags in the millions of dollars. Today, graduate students are sequencing genomes in the course of their dissertations. Biology can be an incredibly data-rich endeavor, and the skills of the modern biologist now often include unfamiliar terms like SQL, R, Perl, Unix, etc. Despite the outward changes, the major biological questions have remained unchanged. However, we can now use new techniques to answer these questions in ways that would have been hard to imagine previously. In this talk, I will discuss how we have addressed some long-standing problems in gene expression (CpG islands, protein-DNA interactions, and intron function) using a little bioinformatics and a lot of sequencing. Helen Geiger, Administrative Assistant Quantitative Biology Graduate Program and Gene Expression in Development and Disease Biochemistry 603 Wilson Road, Room 212 East Lansing, MI 48824 Email: [log in to unmask] Phone: 517-432-9895 QB Website: http://www.qbi.msu.edu/ GEDD Website: http://www.gedd.msu.edu/