Please note these changes for this jointly sponsored SATE seminar: Date: Tuesday, February 26 Time: 11:00am-12:00pm Refreshments: 10:45 SCIENCE AT THE EDGE SEMINAR QB/GEDD Jointly sponsored with Department of Mathematics Tuesday, February 26 at 11:00am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 10:45 Yaoqi Zhou School of Informatics Indiana University-Purdue University at Indianapolis Shedding light on the dark matter in the universe of protein structures and protein-RNA interactions Most biological activities are directed and regulated by proteins. Despite significant efforts, the structures and functions for the majority of proteins remain unknown. On one hand, increasing structure coverage of protein sequences since 2007 has not led to any expansion of the structure space itself. On the other hand, function annotations continue to utilize antiquated homology-searching tools that have limited sensitivity. In this talk, I will discuss two new bioinformatic tools that take you deeper into the protein structure space and protein-RNA interaction space that none has ever been there before. Helen Geiger, Administrative Assistant Quantitative Biology Graduate Program and Gene Expression in Development and Disease Biochemistry 603 Wilson Road, Room 212 East Lansing, MI 48824 Email: [log in to unmask] Phone: 517-432-9895 QB Website: http://www.qbi.msu.edu/ GEDD Website: http://www.gedd.msu.edu/