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SCIENCE AT THE EDGE SEMINAR QB/GEDD Friday, November 30 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Gerry Wright Department of Biochemistry and Biomedical Sciences MG DeGroote Institute for Infectious Disease Research McMaster University, Ontario, Canada Resisting Resistance. Overcoming Antibiotic Resistance with Small Molecules Resistance to antibiotics is among the greatest challenges to modern health care. Resistance to all classes of antibiotics has emerged while new antibiotic drug discovery has lagged resulting in a growing crisis. To address this challenge, new approaches to antibiotic drug discovery and new therapeutic strategies need to be considered. Once such approach is the combination of bioactive compounds with antibiotics to overcome resistance, such antibiotic adjuvants have the capacity to extend the life and spectrum of known drugs. Our efforts to block resistance directly and indirectly using small molecule antibiotic adjuvants will be presented. Helen Geiger, Administrative Assistant Quantitative Biology Graduate Program and Gene Expression in Development and Disease Biochemistry 603 Wilson Road, Room 212 East Lansing, MI 48824 Email: [log in to unmask] Phone: 517-432-9895 QB Website: http://www.qbi.msu.edu/ GEDD Website: http://www.gedd.msu.edu/