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Michigan State University
Science at the Edge
Engineering Seminar
November
9th, 2012
11:30
a.m.
Room
1400 Biomedical and Physical Sciences Building
Refreshments
served at 11:15 a.m.
Jonathan
S. Dordick, Ph.D.
Departments of Chemical and Biological Engineering,
Biomedical Engineering,
Materials Science and Engineering, and Biology
Center for Biotechnology & Interdisciplinary
Studies
Rensselaer Polytechnic Institute
Troy,
NY 12180
High-Throughput 3D Cell
Culture for Drug Discovery and Human Toxicology
Abstract
The need for increased knowledge of drug
candidates at early stages of discovery is driving the development
of new, high-throughput, and high-content technologies.
Traditional ADME/Tox strategies are often slow and focused on
later stage lead compounds and preclinical candidates. However,
the pervasiveness of toxicity in highly potent drug candidates
necessitates that decisions on drug candidate advancement in the
discovery process involve high quality and predictive information
on potential toxicological impacts of the candidates. This talk
will provide an overview of the various chip-based technologies
developed in our group that enable earlier assessment of ADME/Tox
in the drug development process. The centerpiece of our approach
involves the use of a three-dimensional mammalian cell culture
“DataChip” (Data Analysis Toxicology Assay Chip) that consists of
500-1000 individual cell cultures on a microscope size slide
“biochip”. A broad range of human and animal cells have been used
on the DataChip, including primary cells and transformed cell
lines from multiple tissues, as well as human and animal stem
cells. Together with the MetaChip (Metabolizing Toxicology Assay
Chip that consists of a human CYP450 and Phase II enzyme
microarray), it is possible to assess both parent and human
metabolite toxicity against a wide array of different cell types,
and therefore, accelerate toxicity assessment of drug candidates
and chemicals at unprecedented speeds.
For further
information please contact Prof. Christina Chan, Department of
Chemical Engineering and Materials Science at [log in to unmask]
Persons with disabilities have the right to
request and receive reasonable accommodation. Please call the
Department of Chemical Engineering and Materials Science at
355-5135 at least one day prior to the seminar; requests received
after this date will be met when possible.