Michigan State University
Science at the Edge
Engineering Seminar
November
9th,
2012
11:30
a.m.
Room
1400 Biomedical
and Physical Sciences Building
Refreshments
served
at 11:15 a.m.
Jonathan
S. Dordick,
Ph.D.
Departments
of Chemical and Biological Engineering, Biomedical Engineering,
Materials
Science and Engineering, and Biology
Center
for Biotechnology & Interdisciplinary Studies
Rensselaer
Polytechnic Institute
Troy,
NY 12180
High-Throughput 3D Cell
Culture for Drug Discovery and
Human Toxicology
Abstract
The need for increased knowledge of drug
candidates at early
stages of discovery is driving the development of new,
high-throughput, and
high-content technologies. Traditional ADME/Tox strategies are
often slow and
focused on later stage lead compounds and preclinical candidates.
However, the
pervasiveness of toxicity in highly potent drug candidates
necessitates that
decisions on drug candidate advancement in the discovery process
involve high
quality and predictive information on potential toxicological
impacts of the
candidates. This talk will provide an overview of the various
chip-based
technologies developed in our group that enable earlier assessment
of ADME/Tox
in the drug development process. The centerpiece of our approach
involves the
use of a three-dimensional mammalian cell culture “DataChip” (Data
Analysis
Toxicology Assay Chip) that consists of 500-1000 individual cell
cultures on a
microscope size slide “biochip”. A broad range of human and animal
cells have
been used on the DataChip, including primary cells and transformed
cell lines
from multiple tissues, as well as human and animal stem cells.
Together with
the MetaChip (Metabolizing Toxicology Assay Chip that consists of
a human
CYP450 and Phase II enzyme microarray), it is possible to assess
both parent
and human metabolite toxicity against a wide array of different
cell types, and
therefore, accelerate toxicity assessment of drug candidates and
chemicals at
unprecedented speeds.
For further
information
please contact Prof. Christina Chan, Department of Chemical
Engineering and
Materials Science at [log in to unmask]
Persons with disabilities have the right to
request and
receive reasonable accommodation. Please call the Department of
Chemical
Engineering and Materials Science at 355-5135 at least one day
prior to the
seminar; requests received after this date will be met when
possible.