Abstract: Adult stem cells are the source of continuous supply of differentiated cells.  Upon stem cell division, its daughters either self-renewal or differentiate, a balance of which is critical to tissue homeostasis. To maintain this critical balance, many stem cells have a potential to divide asymmetrically, giving rise to one stem cell and one differentiating cell.

Drosophila male germ line stem cells (GSCs) divide always asymmetrically, producing one self-renewed stem cell and one differentiating cell. This asymmetric stem cell division is tightly controlled via stereotypical positioning of mother and daughter centrosomes, leading to oriented spindle with respect to the stem cell niche and thus asymmetric stem cell division. 

I will discuss the mechanisms of asymmetric stem cell division, how asymmetric stem cell divisions are coordinated among multiple stem cell populations and describe about newly discovered asymmetries during the stem cell division.

From: Ruby N. Ghosh [mailto:[log in to unmask]]
Sent: Tuesday, September 04, 2012 8:16 AM
To: Shawna Prater
Subject: please send attached flyer to the entire science at the edge mailing list

FRIDAY, September 7, 2012

Interdisciplinary Physics

Science at the Edge Seminar, 11:30 a.m., Room 1400 BPS Bldg.

Speaker:  Yukiko Yamashita, University of Michigan

                                                                                                            Center for Stem Cell Biology, Life Sciences Institute

Title:  Asymmetric Stem Cell Division in Drosophila

http://www.med.umich.edu/cdb/people/yukikomy.html

*

[log in to unmask]" alt="Description: Description: Headshot of Yukiko Yamashita">

Shawna Prater / Secretary

Astrophysics Group

Michigan State University

567 Wilson Road, Room 3261

Biomedical Physical Sciences Bldg

East Lansing, MI 48824-2320

Ph: (517) 884-5601 Fax (517) 432-8802

[log in to unmask], [log in to unmask]

-- 
Ruby N. Ghosh
Research Associate Professor
Dept. of Physics & Astronomy       
4218 BioMed. Physical Sciences office phone: (517) 884 5585
567 Wilson Road                 lab phone: (517) 884 5684
Michigan State University      FAX: (517) 353 4500
East Lansing, MI 48824-2320    
www.pa.msu.edu/people/ghosh/
 
Adjunct Research Associate Professor
Dept. of Electrical & Computer Engineering