Abstract: Adult stem cells are the source of continuous supply of differentiated cells. Upon stem cell division, its daughters either self-renewal or differentiate, a balance of which is critical to tissue homeostasis. To maintain this critical balance, many stem cells have a potential to divide asymmetrically, giving rise to one stem cell and one differentiating cell. Drosophila male germ line stem cells (GSCs) divide always asymmetrically, producing one self-renewed stem cell and one differentiating cell. This asymmetric stem cell division is tightly controlled via stereotypical positioning of mother and daughter centrosomes, leading to oriented spindle with respect to the stem cell niche and thus asymmetric stem cell division. I will discuss the mechanisms of asymmetric stem cell division, how asymmetric stem cell divisions are coordinated among multiple stem cell populations and describe about newly discovered asymmetries during the stem cell division. From: Ruby N. Ghosh [mailto:[log in to unmask]] Sent: Tuesday, September 04, 2012 8:16 AM To: Shawna Prater Subject: please send attached flyer to the entire science at the edge mailing list FRIDAY, September 7, 2012 Interdisciplinary Physics Science at the Edge Seminar, 11:30 a.m., Room 1400 BPS Bldg. Speaker: Yukiko Yamashita, University of Michigan Center for Stem Cell Biology, Life Sciences Institute Title: Asymmetric Stem Cell Division in Drosophila http://www.med.umich.edu/cdb/people/yukikomy.html * [Description: Description: Headshot of Yukiko Yamashita]<http://www.med.umich.edu/cdb/people/yukikomy.html> Shawna Prater / Secretary Astrophysics Group Michigan State University 567 Wilson Road, Room 3261 Biomedical Physical Sciences Bldg East Lansing, MI 48824-2320 Ph: (517) 884-5601 Fax (517) 432-8802 [log in to unmask]<mailto:[log in to unmask]>, [log in to unmask]<mailto:[log in to unmask]> -- Ruby N. Ghosh Research Associate Professor Dept. of Physics & Astronomy 4218 BioMed. Physical Sciences office phone: (517) 884 5585 567 Wilson Road lab phone: (517) 884 5684 Michigan State University FAX: (517) 353 4500 East Lansing, MI 48824-2320 www.pa.msu.edu/people/ghosh/<http://www.pa.msu.edu/people/ghosh/> Adjunct Research Associate Professor Dept. of Electrical & Computer Engineering