Interdisciplinary Physics Science on the Edge Presents
FRIDAY, March 16, 2012
Science at the Edge Seminar, 11:30 a.m., Room 1400 BPS Bldg.
Speaker: Doraiswami Ramkrishna, Purdue University
Title: Dynamic Modeling of Metabolism. The Cybernetic Approach
Dynamic Modeling of Metabolic Systems. The Cybernetic Approach.
Doraiswami Ramkrishna
H. C. Peffer Distiguished Professor
School of Chemical Engineering
Purdue University
West Lafayette, IN 47907
ABSTRACT
Metabolic networks feature a multitude of chemical reactions involving uptake of external nutrients and transforming them to various intracellular metabolites, fermentation products which are released into the surrounding medium, and biomass. These reactions are catalyzed by highly specific enzymes whose levels and activities are subject to control within a metabolic regulatory system dictated by the genomic background of the organism. Dynamic modeling of metabolic systems is essential to develop quantitative understanding of biological systems and to facilitate design, optimization and control of biotechnological processes.
This presentation will discuss dynamic modeling of metabolic systems from our cybernetic approach and compared with other modeling perspectives. The cybernetic approach is based on viewing regulatory processes as being inspired by survival of one form or another. It postulates optimal investment of the organism's resources for selective synthesis of enzymes that will drive reactions favoring the organism's survival. The theory features the usual concentration variables associated with reaction kinetics as well as cybernetic variables that are control variables shown to depend only on reaction kinetics from optimal control theory. These control variables concern both enzyme syntheses and enzyme activities.
Successful applications of cybernetic models to metabolism of bacteria and yeast are presented. The cybernetic models represent the most promising tool for metabolic engineering as they have a means to account for metabolic burden imposed by pathway changes.
Shawna Prater / Secretary
Astrophysics Group
Michigan State University
567 Wilson Road, Room 3261
Biomedical Physical Sciences Bldg
East Lansing, MI 48824-2320
Ph: (517) 884-5601 Fax (517) 432-8802
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