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What are you using for antivirus protection (AV) on your 64-bit MS Windows Server 2008 non-Exchange boxes?
ESET and Windows Defender do not have 64-bit versions available. Symantec and Kaspersky say they do, but I have read that the apps are really 32-bit so you get a performance hit. The only one I've found so far that is supposed to be a native 64-bit app is Outpost. Have you used Outpost? What do you think of it? Do you know of any other native 64-bit AV products for WinSvr 2008?
~ Esther
Esther V. V. Reed
IT Systems Administrator
MSU Graduate School