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I have recent experience that corroborates what Ed surmises.  On a new
computer running Windows XP Pro, I installed Office 2003 and attempted
to send mail via Outlook.  It failed consistently when sending via
mail.msu.edu.  I had it configured to use port 465 directly. I did an
Office Update, and Outlook sends via mail.msu.edu just fine now.

/rich

On Wed, 18 Aug 2004 11:32:06 -0400, Ed Symanzik <[log in to unmask]> wrote:
> mail.msu.edu listens on both ports.  Port 465 is SSL encrypted only.  Port 25
> uses TLS to switch to encryption.  I have found no consistent behavior from
> clients explaining when they need one or the other.  Your own configuration, for
> example, uses port 25 then, with no apparent reason, needs port 465.  (this is
> with Eudora?)
>
> A wild guess for you is that for 4 weeks you were sending mail to users @msu.edu
> which does not require authentication and encryption.  At week 4 you sent to a
> non-msu.edu address and relay was denied.
>
> Another wild guess is that there is some auto-patch from MS that causes things
> to work differently.
>
> --
> Ed Symanzik
> MSU Mail Team
> [log in to unmask]
>