________________________________________
From: Christina Chan [[log in to unmask]]
Sent: Thursday, March 24, 2011 7:00 AM
To: Geiger, Helen
Subject: CHeMS Seminar Announcement - Thursday March 24
Hi Helen,
Can you send this out to the SATE listserv?
thanks,
Kris
-------- Original Message --------
Subject: CHeMS Seminar Announcement - Thursday March 24
Date: Wed, 23 Mar 2011 12:14:30 -0400
From: Lauren Brown <[log in to unmask]>
To: [log in to unmask], [log in to unmask],
[log in to unmask], [log in to unmask], [log in to unmask]
Chemical Engineering and Materials Science
*Thursday March 24, 2011*
*9:10 a.m.*
*2250 Engineering Building*
* *
*Title*
* *
*Millicent Sullivan*
Department of Chemical Engineering
University of Delaware
*Cellular Processing of Drug and Gene Delivery Biomaterials*
Drug and gene therapies have the potential to deeply alter human disease
treatment by providing safe and permanent cures to a variety of
debilitating diseases, enabling the genetic manipulation of stem cells,
and facilitating regenerative medicine, yet in many cases, therapeutic
efficacy has yet to be realized. Tissue and cell targeting are crucial
to maximize therapeutic efficacy and limit off-targeting effects.
Simultaneously, improved control over subcellular
processing/trafficking, especially in the context of the /in vivo/
environment, has been identified as an absolutely critical hurdle. The
broad goal of our work is to develop simple strategies for targeted and
efficient delivery within remodeling tissues. Tissue repair and
extracellular matrix (ECM) turnover are profoundly important in a
variety of pathological processes, including hypertension, restenosis,
fibrosis, and cancer. Thus, because successful delivery materials must
selectively partition into these tissues and enter diseased cells, our
approach is to exploit natural ECM remodeling processes for delivery
into diseased tissues. To that end, we have developed new methods for
the presentation of cell-targeting peptides that rely on the natural
upregulation of proteins involved in cellular migration and ECM turnover
to facilitate utilization. Results demonstrating matrix
metalloproteinase (MMP)-1/2-responsive nucleic acid targeting and
delivery will be presented. Work on the coupling of cell targeting with
programmed subcellular trafficking and processing will also be
presented, including recent studies demonstrating the efficacy of
histone-derived peptides to enhance nuclear delivery and processing of DNA.
Persons with disabilities have the right to request and receive
reasonable accommodation. Please call the Department of Chemical
Engineering and Materials Science at 355-5135 at least one day prior to
the seminar; requests received after this date will be met when possible.
--
Lauren Brown
Graduate Program Secretary
Michigan State University
Department of Chemical Engineering and Materials Science
2527 Engineering Building
East Lansing MI 48864
(517)355-5135 ph.
(517)432-1105 fax
|
