MSU Listserv


SCI-AT-THE-EDGE Archives

SCI-AT-THE-EDGE Archives


SCI-AT-THE-EDGE@LIST.MSU.EDU


View:

Message:

[

First

|

Previous

|

Next

|

Last

]

By Topic:

[

First

|

Previous

|

Next

|

Last

]

By Author:

[

First

|

Previous

|

Next

|

Last

]

Font:

Proportional Font

LISTSERV at MSU

LISTSERV at MSU

SCI-AT-THE-EDGE Home

SCI-AT-THE-EDGE Home

SCI-AT-THE-EDGE  March 2011

SCI-AT-THE-EDGE March 2011

Subject:

Re: CHeMS Seminar Announcement - Thursday March 24

From:

"Geiger, Helen" <[log in to unmask]>

Reply-To:

Geiger, Helen

Date:

Thu, 24 Mar 2011 12:16:43 +0000

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (92 lines)

________________________________________
From: Christina Chan [[log in to unmask]]
Sent: Thursday, March 24, 2011 7:00 AM
To: Geiger, Helen
Subject: CHeMS Seminar Announcement - Thursday March 24

Hi Helen,

Can you send this out to the SATE listserv?

thanks,
Kris

-------- Original Message --------
Subject:        CHeMS Seminar Announcement - Thursday March 24
Date:   Wed, 23 Mar 2011 12:14:30 -0400
From:   Lauren Brown <[log in to unmask]>
To:     [log in to unmask], [log in to unmask],
[log in to unmask], [log in to unmask], [log in to unmask]



Chemical Engineering and Materials Science



*Thursday March 24, 2011*

*9:10 a.m.*

*2250 Engineering Building*

* *

*Title*

* *

*Millicent Sullivan*

Department of Chemical Engineering

University of Delaware



*Cellular Processing of Drug and Gene Delivery Biomaterials*



Drug and gene therapies have the potential to deeply alter human disease
treatment by providing safe and permanent cures to a variety of
debilitating diseases, enabling the genetic manipulation of stem cells,
and facilitating regenerative medicine, yet in many cases, therapeutic
efficacy has yet to be realized.  Tissue and cell targeting are crucial
to maximize therapeutic efficacy and limit off-targeting effects.
Simultaneously, improved control over subcellular
processing/trafficking, especially in the context of the /in vivo/
environment, has been identified as an absolutely critical hurdle.  The
broad goal of our work is to develop simple strategies for targeted and
efficient delivery within remodeling tissues.  Tissue repair and
extracellular matrix (ECM) turnover are profoundly important in a
variety of pathological processes, including hypertension, restenosis,
fibrosis, and cancer.  Thus, because successful delivery materials must
selectively partition into these tissues and enter diseased cells, our
approach is to exploit natural ECM remodeling processes for delivery
into diseased tissues.  To that end, we have developed new methods for
the presentation of cell-targeting peptides that rely on the natural
upregulation of proteins involved in cellular migration and ECM turnover
to facilitate utilization.  Results demonstrating matrix
metalloproteinase (MMP)-1/2-responsive nucleic acid targeting and
delivery will be presented.  Work on the coupling of cell targeting with
programmed subcellular trafficking and processing will also be
presented, including recent studies demonstrating the efficacy of
histone-derived peptides to enhance nuclear delivery and processing of DNA.



Persons with disabilities have the right to request and receive
reasonable accommodation. Please call the Department of Chemical
Engineering and Materials Science at 355-5135 at least one day prior to
the seminar; requests received after this date will be met when possible.

--
Lauren Brown
Graduate Program Secretary
Michigan State University
Department of Chemical Engineering and Materials Science
2527 Engineering Building
East Lansing MI 48864
(517)355-5135 ph.
(517)432-1105 fax

Top of Message | Previous Page | Permalink

Advanced Options


Options

Log In

Log In

Get Password

Get Password


Search Archives

Search Archives


Subscribe or Unsubscribe

Subscribe or Unsubscribe


Archives

October 2021
May 2021
November 2020
September 2020
March 2020
February 2020
January 2020
November 2019
October 2019
September 2019
August 2019
April 2019
March 2019
February 2019
November 2018
October 2018
September 2018
August 2018
April 2018
March 2018
February 2018
January 2018
November 2017
October 2017
September 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010

ATOM RSS1 RSS2



LIST.MSU.EDU

CataList Email List Search Powered by the LISTSERV Email List Manager