Science at the Edge
September 29th 2017
1400 Biomedical Physical Sciences
11:30 am
James Bardwell,
Rowena G. Matthews Collegiate Professor, University of Michigan, Howard Hughes Investigator
“Watching a Chaperone Fold a Protein at High Resolution”
Dr. Bardwell was a graduate student at the University of Wisconsin with Elizabeth Craig. He was a postdoctoral researcher with John Beckwith at Harvard University. He was
a Visiting Professor and Alexander von Humboldt Fellow at the Institute of Biophysics and Physical Biochemistry, University of Regensburg, Germany, before joining the faculty at the University of Michigan.
Chaperone characterization in the Bardwell Laboratory
The Bardwell laboratory has addressed four of the central mysteries of chaperone biology: how chaperones rapidly bind to proteins, how the chaperone-substrate
complex is stabilized, how a chaperone can facilitate substrate folding, and what triggers substrate release1,2. The laboratory has also devised a novel structural biology approach that enabled us to visualize the dance of chaperone-mediated folding1,4
demonstrating that client folding occurs while bound to the chaperone3.
Bardwell publications can be found by following this link:
https://www.ncbi.nlm.nih.gov/pubmed?term=bardwell
jc%5BAuthor%5D
Lerena R. Heintzelman
Department of Physics & Astronomy
Michigan State University
567 Wilson Rd. Room 3261
East Lansing, MI 48824
517-884-5513