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SCIENCE AT THE EDGE SEMINAR QB/GEDD Friday, September 9 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Haixu Tang Department of Informatics and Computing, Indiana University Next Generation Software Tools for Next Generation Sequence Analysis The rapid advance of the massively parallel sequencing (often referred to as the Next Generation Sequencing, NGS) technologies has revolutionized DNA sequencing by reducing both its throughtput and cost by several magnitudes in the past few years. As a result, DNA sequencing has become available for not only large genome centers, but also individual biological labs, a trend called the democratized genomics. With the fast-growing applications of NGS on a wide spectrum of biological problems, ranging from gene expression analysis (i.e. RNA-seq) to metagenomics, pressures are mounting on the bioinformatics community to come up with software systems to analyze such data. In this talk, I will present a few case studies to address the computational challenges to design and implement these sequence analysis systems, with focuses on the requirements of Simplicity, Scalability, Speed and Security of the systems. Helen Geiger Administrative Assistant Quantitative Biology Graduate Program and Gene Expression in Development and Disease 502B Biochemistry Building Michigan State University East Lansing, MI 48824 Email: [log in to unmask] QB Website: http://www.qbi.msu.edu/ GEDD Website: http://www.gedd.msu.edu/