SCIENCE AT THE EDGE SEMINAR QBI/GEDD Friday, April 2 at 11:30am Room 1400 Biomedical and Physical Sciences Bldg. Refreshments at 11:15 Karl W. Broman Department of Biostatistics & Medical Informatics, University of Wisconsin-Madison Mapping QTL to a Phylogenetic Tree The joint consideration of multiple crosses between related taxa (whether species or strains) not only allows more precise mapping of the genetic loci (called quantitative trait loci, QTL) that contribute to important quantitative traits, but also offers the opportunity to identify the origin of a QTL allele on the phylogenetic tree that relates the taxa. We will discuss a formal method for combining multiple crosses to infer the location of a QTL on a tree, and will further discuss various experimental design issues for such endeavors, such as how many crosses are required and which sets of crosses are best. Helen Geiger Administrative Assistant Quantitative Biology Initiative/ Gene Expression in Development & Disease Michigan State University 502B Biochemistry Building East Lansing, MI 48824 Phone: (517) 432-9895 Fax: (517) 353-9334 E-mail: [log in to unmask]<mailto:[log in to unmask]> Web: http://qbmi.msu.edu<http://qbmi.msu.edu/> http://www.bch.msu.edu/GEDD/index.htm<http://www.bch.msu.edu/GEDD/MSU-TRSB-Symposium.htm>