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SCIENCE AT THE EDGE SEMINAR
QBI/GEDD
Friday, April 2 at 11:30am
Room 1400 Biomedical and Physical Sciences Bldg.
Refreshments at 11:15
Karl W. Broman
Department of Biostatistics & Medical Informatics,
University of Wisconsin-Madison
Mapping QTL to a Phylogenetic Tree
The joint consideration of multiple crosses between related taxa (whether species or strains) not only allows more precise mapping of the genetic loci (called quantitative trait loci, QTL) that contribute to important quantitative traits,
but also offers the opportunity to identify the origin of a QTL allele on the phylogenetic tree that relates the taxa. We will discuss a formal method for combining multiple crosses to infer the location of a QTL on a tree, and will further discuss various
experimental design issues for such endeavors, such as how many crosses are required and which sets of crosses are best.
Helen Geiger
Administrative Assistant
Quantitative Biology Initiative/
Gene Expression in Development & Disease
Michigan State University
502B Biochemistry Building
East Lansing, MI 48824
Phone: (517) 432-9895
Fax: (517) 353-9334
Web:
http://qbmi.msu.edu
http://www.bch.msu.edu/GEDD/index.htm